Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

6.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
Autophagic Cell Death01:18

Autophagic Cell Death

4.8K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.8K
Hypoxia01:23

Hypoxia

2.4K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.4K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

10.4K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The subpleural pulmonary microvasculature in newborn yak (Bos grunniens).

Veterinary research communications·2008
Same author

Experimental confirmation of potential swept source optical coherence tomography performance limitations.

Applied optics·2008
Same author

A germin-like protein gene family functions as a complex quantitative trait locus conferring broad-spectrum disease resistance in rice.

Plant physiology·2008
Same author

[Spatial and temporal changes of palatal cell proliferation and cell apoptosis of retinoic acid induced mouse cleft palate in different embryonic stages].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2008
Same author

Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties.

Developmental and comparative immunology·2008
Same author

Non-Gaussian statistics and superdiffusion in a driven-dissipative dusty plasma.

Physical review. E, Statistical, nonlinear, and soft matter physics·2008

Related Experiment Video

Updated: Feb 28, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

36.4K

[Autophagy and hypoxic ischemic brain injuries].

Yong-Qiang Li1, Su Fu1, Lai Wang1

  • 1Institute of Neurobiology, Nursing College, Henan University, Kaifeng 475004, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|June 23, 2017
PubMed
Summary

Autophagy, a cellular recycling process, plays a complex role in hypoxic ischemic brain injuries like stroke. Further research is needed to clarify its exact function and mechanisms in these conditions.

More Related Videos

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
08:32

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

13.0K
Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

10.6K

Related Experiment Videos

Last Updated: Feb 28, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

36.4K
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
08:32

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

13.0K
Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

10.6K

Area of Science:

  • Cellular Biology
  • Neuroscience
  • Physiology

Background:

  • Autophagy is a fundamental cellular process conserved across species, crucial for maintaining cellular homeostasis by clearing damaged components.
  • While essential for normal cell function, dysregulation of autophagy is implicated in various diseases, though mechanisms remain unclear.
  • The role of autophagy in hypoxic ischemic brain injuries, such as stroke, is a significant area of research with ongoing debate.

Purpose of the Study:

  • To review the current understanding of autophagy activation, function, and mechanisms in the context of hypoxic ischemic brain injuries.
  • To synthesize existing research on the complex relationship between autophagy and stroke.
  • To offer perspectives for future research directions in this field.

Main Methods:

  • Literature review of studies on autophagy and hypoxic ischemic brain injuries.
  • Analysis of research on the stages of autophagy: autophagosome formation, lysosome-autophagosome fusion, and degradation.
  • Examination of the role of autophagy in cellular homeostasis and disease development.

Main Results:

  • Autophagy is a conserved physiological mechanism involving distinct stages for cellular cleanup.
  • Autophagy is critical for maintaining cellular and organismal homeostasis under physiological conditions.
  • The precise role and underlying mechanisms of autophagy in hypoxic ischemic brain injuries remain incompletely understood.

Conclusions:

  • Autophagy's involvement in hypoxic ischemic brain injuries is a complex and actively researched topic.
  • Clarifying autophagy's precise role and mechanisms is essential for understanding stroke pathophysiology.
  • Further investigation is warranted to provide definitive insights into autophagy's function in brain injury.