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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Published on: August 18, 2020

Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry.

José Boto¹, Georgios Gkinis², Alexis Roche^3,4,5

¹Division of Neuroradiology, Geneva University Hospital and Faculty of Medicine of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. jose.m.baiaoboto@hcuge.ch.

European Radiology

|June 23, 2017

Summary

This summary is machine-generated.

Brain atrophy was detected in anorexia nervosa patients using automated brain segmentation with MP2RAGE MRI. This technique reliably estimates brain volume and can track changes in anorexia nervosa.

Keywords:

3-D imaging Anorexia nervosa Atrophy Brain Magnetic resonance imaging

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Area of Science:

Neuroimaging
Radiology
Medical Science

Background:

Anorexia nervosa is associated with potential brain structure alterations.
Accurate assessment of brain volume is crucial for understanding the pathophysiology of eating disorders.

Purpose of the Study:

To evaluate brain atrophy in patients with anorexia nervosa using automated cerebral segmentation.
To assess the reliability of the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence for brain volume estimation.

Main Methods:

Twenty female patients with anorexia nervosa (BMI < 18.5 kg/m²) and ten healthy female controls underwent 3D MRI using MP2RAGE.
Automated brain morphometry was performed, comparing brain volumes between groups.
Correlation analysis was conducted between brain volumes and Body Mass Index (BMI).

Main Results:

Anorexic patients showed significantly lower volumes of total brain, grey matter, white matter, cerebellum, and insula.
Higher cerebrospinal fluid (CSF) and ventricular volumes were observed in anorexic patients.
Positive correlations were found between BMI and total brain, grey matter, cortical grey matter, and white matter volumes.

Conclusions:

Automated brain segmentation using MP2RAGE MRI reliably detects brain atrophy in anorexia nervosa.
This technique enables quantitative and qualitative follow-up of brain changes in patients with anorexia nervosa.
MP2RAGE-based automated segmentation is a valuable tool for studying brain alterations in eating disorders.