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Updated: Feb 28, 2026

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
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Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination

Raymond Liang1,2, Saghi Ghaffari3,4,5,6

  • 1Department of Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Journal of Bioenergetics and Biomembranes
|June 23, 2017
PubMed

The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination.

Keywords:
FOXOFOXO3HSCMitochondriaROSStem cellUPR

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