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Selective laser melting-enabled electrospinning: Introducing complexity within electrospun membranes.

Thomas E Paterson1, Selina N Beal1, Martin E Santocildes-Romero1

  • 1Bioengineering and Health Technologies Group, The School of Clinical Dentistry, The University of Sheffield, Sheffield, UK.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|June 23, 2017
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Summary

Researchers developed advanced biodegradable membranes using additive manufacturing and electrospinning. These novel biomaterials support cell growth, offering potential for tissue regeneration and therapeutic implants.

Keywords:
Additive manufacturingbone healingelectrospinningselective laser meltingstem cell niche

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Additive Manufacturing

Background:

  • Additive manufacturing (AM) allows precise structure creation mimicking natural tissues.
  • Biodegradable membranes are crucial for tissue regeneration and implantable devices.
  • Controlled microenvironments enhance biomaterial functionality.

Purpose of the Study:

  • To develop an AM-based platform for producing biodegradable membranes with controlled microenvironments.
  • To characterize the microstructures and cellular interactions of these novel membranes.
  • To evaluate the potential of these membranes in tissue regeneration applications, such as bone healing.

Main Methods:

  • Combination of selective laser melting (SLM) and electrospinning for membrane fabrication.
  • Scanning electron microscopy (SEM) for microstructural analysis (fiber diameter, density).
  • Mesenchymal stromal cell (MSC) culture to assess cell proliferation and infiltration.

Main Results:

  • Successful fabrication of biodegradable membranes with distinct microenvironment designs (niches).
  • SEM confirmed variations in fiber diameter and density within the niche structures.
  • Demonstrated robust support for mesenchymal stromal cell culture, proliferation, and infiltration within the membranes.

Conclusions:

  • The developed technology platform enables the creation of versatile biomaterial devices with controlled microenvironments.
  • These microfabricated membranes show significant potential as research tools and components for therapeutic implants.
  • The findings support the application of these membranes in various tissue regeneration strategies, including bone healing.