Recent Advances in Radical C-H Activation/Radical Cross-Coupling

Area of Science:

• Organic Chemistry
• Catalysis
• Synthetic Methodology

Background:

• Radical C-H activation and cross-coupling reactions have gained significant research and industrial interest.
• These methods provide atom- and step-economical alternatives to traditional synthetic routes.
• Advances in photocatalysis, first-row transition metal catalysis, and peroxide initiators have been crucial.

Purpose of the Study:

• To provide a concise overview of the current status of radical C-H activation.
• To highlight the latest methodologies utilizing radicals or radical cations as key intermediates.
• To cover diverse radical reaction types, including additions, cyclizations, and cross-couplings.

Main Methods:

• Review of recent literature on radical C-H activation and cross-coupling.
• Focus on methodologies employing radicals or radical cations generated via C-H activation.
• Categorization of reactions into radical addition, cascade cyclization, and various cross-coupling types.

Main Results:

• Compilation of diverse radical reaction methodologies.
• Demonstration of radical intermediates generated through C-H activation.
• Inclusion of reactions involving radicals with M-R groups and radical cations with nucleophiles.

Conclusions:

• Radical C-H activation offers versatile and efficient synthetic strategies.
• Photocatalysis and transition metal catalysis are key enablers of these reactions.
• The reviewed methodologies represent the forefront of radical chemistry in synthesis.