[Pharmacodynamics of vecuronium. A clinical study]

54 Patients (ASA I + II) were paralysed with different doses of vecuronium during neuroleptanesthesia. Time course of action was registered by means of mechanical twitch response. ED 95 as calculated by linear regression amounted to 63 micrograms/kg (ED 50: 27 micrograms/kg). After administration of ED 95 about 3/4 of the patients are completely paralysed. After administration of 70 micrograms/kg 9/10 of the patients are completely paralysed. Mean duration of action of these two doses is 28 and 35 min respectively. Vecuronium doses from 60 micrograms/kg on are suitable for orotracheal intubation. However onset time of action is 3-4 min. Circulatory side effects after administration of vecuronium were not observed.