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Published on: April 7, 2015
Panton-Valentine Leukocidin Producing Staphylococcus Aureus Facial Pyomyositis Causing Partial Cavernous Sinus
Katherine Green1, Ioanna Chranioti, Saurabh Singh
1From the *Department of Paediatrics, Royal Free London NHS Foundation Trust, †Paediatric & Adolescent Division, University College London Hospitals NHS Foundation Trust, ‡Centre of Medical Imaging, University College London, §UCL Institute of Neurology Academic Neuroradiological Unit, University College London, and ¶KD Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London, United Kingdom.
Abstract:
We present a case of subtotal cavernous sinus thrombosis secondary to Panton-Valentine leukocidin-associated Staphylococcus aureus pyomyositis of the muscles of mastication in a previously healthy child, who was successfully managed with no residual disease. He was found to have a factor V Leiden heterozygous mutation. We highlight the propensity of Panton-Valentine leukocidin Staphylococcus aureus to induce venous thrombosis at any site but with potential for more severe consequences in the head. We highlight pyomyositis as a differential for periorbital cellulitis and discuss the significance of the factor V Leiden mutation.
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Etiology
Three primary contributing factors have been identified.

