Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proofreading01:43

Proofreading

61.7K
Overview
61.7K
Proofreading01:31

Proofreading

9.3K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
9.3K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.6K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.6K
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

1.1K
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
1.1K
Accuracy and Errors in Hypothesis Testing01:13

Accuracy and Errors in Hypothesis Testing

636
Hypothesis testing is a fundamental statistical tool that begins with the assumption that the null hypothesis H0 is true. During this process, two types of errors can occur: Type I and Type II. A Type I error refers to the incorrect rejection of a true null hypothesis, while a Type II error involves the failure to reject a false null hypothesis.
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
636
Mutations01:39

Mutations

95.0K
Overview
95.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Heat Stress-Mediated Multi-Organ Injury: Pathophysiology and Treatment Strategies.

Comprehensive Physiologyยท2026
Same journal

Targeting the Organ-Brain Axis: The Modulatory Role of Peripheral Organs in Depression.

Comprehensive Physiologyยท2026
Same journal

The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described?

Comprehensive Physiologyยท2026
Same journal

The Evolution of Taste: Genetic, Dietary, and Cultural Pathways in Human Taste Perception.

Comprehensive Physiologyยท2026
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiologyยท2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiologyยท2026

Related Experiment Video

Updated: Feb 27, 2026

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

847

Corrigendum

    Comprehensive Physiology
    |June 23, 2017
    PubMed
    Summary

    Diabetic cardiomyopathy (DCM) involves heart dysfunction in diabetic patients, independent of other heart conditions. Research explores its complex causes, including metabolic changes and potential epigenetic factors for prevention and therapy.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Molecular Biology

    Background:

    • Diabetic cardiomyopathy (DCM) affects type 1 and type 2 diabetic patients independently of other cardiovascular diseases.
    • Its precise mechanisms remain incompletely understood, despite being recognized over 40 years ago.

    Purpose of the Study:

    • To review the current understanding of pathophysiological bases for DCM.
    • To explore the role of epigenetic modulation in diabetes-induced cardiac complications.

    Main Methods:

    • Review of extensive clinical and experimental studies.
    • Analysis of proposed pathophysiological mechanisms including hyperglycemia, metabolic disturbances, mitochondrial dysfunction, and inflammation.

    Main Results:

    More Related Videos

    Transcutaneous Microcirculatory Imaging in Preterm Neonates
    06:27

    Transcutaneous Microcirculatory Imaging in Preterm Neonates

    Published on: December 31, 2015

    8.6K
    Operation of the Collaborative Composite Manufacturing CCM System
    10:09

    Operation of the Collaborative Composite Manufacturing CCM System

    Published on: October 1, 2019

    7.2K

    Related Experiment Videos

    Last Updated: Feb 27, 2026

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
    05:46

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

    Published on: September 20, 2024

    847
    Transcutaneous Microcirculatory Imaging in Preterm Neonates
    06:27

    Transcutaneous Microcirculatory Imaging in Preterm Neonates

    Published on: December 31, 2015

    8.6K
    Operation of the Collaborative Composite Manufacturing CCM System
    10:09

    Operation of the Collaborative Composite Manufacturing CCM System

    Published on: October 1, 2019

    7.2K
  • Proposed DCM mechanisms include hyperglycemia, nonenzymatic glycosylation, metabolic and mitochondrial dysfunction, impaired calcium handling, oxidative stress, inflammation, cell death, hypertrophy, and fibrosis.
  • Evidence suggests "metabolic memory" and epigenetic modulation play significant roles in DCM development.

    • Conclusions:

    • Understanding DCM pathophysiology and epigenetic mechanisms is crucial for developing prevention and therapy strategies.
    • Further research into epigenetic regulation is needed to fully elucidate DCM development in diabetic patients.