Total Synthesis of Huperzine Q

Related Experiment Video

Updated: Feb 27, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.2K

Shun Tanimura1,2, Satoshi Yokoshima1, Tohru Fukuyama1

  • 1Graduate School of Pharmaceutical Sciences, Nagoya University , Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.

Organic Letters
|June 23, 2017
PubMed

Abstract:

The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels-Alder reaction and a ring contraction reaction of an epoxyketone.

More Related Videos

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

3.5K
Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry
07:16

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

1.1K

Related Experiment Videos

Last Updated: Feb 27, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.2K
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

3.5K
Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry
07:16

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

1.1K

Related Concept Videos

Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

2.0K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
2.0K

Articles linked to this work by shared authors, journal, and citation graph.

AI-Derived Carpal Compactness Metrics as Quantitative Imaging Measures of Global Carpal Architecture in Early Rheumatoid Arthritis.

Journal of imaging·2026

Association of Intraerosive Power Doppler Signals Detected by Musculoskeletal Ultrasound With 1-Year Radiographic Progression in Early Rheumatoid Arthritis.

The Journal of rheumatology·2026

Total Synthesis of Scandine.

JACS Au·2026

Synthesis of Multisubstituted Diazatricyclic Molecules Via Intramolecular Cycloaddition of Cyclic Azomethine Ylides.

Organic letters·2026

Renieramycin-type bis-1,2,3,4-tetrahydroisoquinoline marine natural products.

The Alkaloids. Chemistry and biology·2026

Design, synthesis, and structural analysis of an inhibitor of the gastric proton pump with a diaza-tricyclic skeleton.

Organic & biomolecular chemistry·2026

A One-Pot Synthesis of Vinyl Sulfoximines and Their Kinetic Evaluation as Tunable Covalent Warheads.

Organic letters·2026

Selective C-S/C-O Bond Formation toward Biaryl Sulfones and Sulfinate Esters Involved with Cyclic Diaryliodoniums.

Organic letters·2026

Late-Stage Catalytic Borylation of Unprotected Peptides.

Organic letters·2026

PEG6k-Catalyzed Green Synthesis of Mono- and Dispirocyclopropanes.

Organic letters·2026

Directed Evolution of Artificial Enzyme with a Catalytic Noncanonical Amino Acid for Asymmetric Friedel-Crafts Alkylation of Cyclic Enones with Indoles.

Organic letters·2026

Construction of Acenaphtho[1,2-b]quinolines through Cyclization of 8-Alkynyl-1-naphthonitriles with Diaryliodonium Salts.

Organic letters·2026

Alkaline hydrothermal humification of furfural residue: A proposed transformation pathway for lignin aromatic skeletons and cellulose‑derived intermediates.

Bioresource technology·2026

Headspace GC-MS screening of MOS-VOC interfacial reactivity for rapid and resource-efficient gas-sensing metal oxides evaluation.

Talanta·2026

Orthogonal tandem catalysis in terpene biosynthesis.

Current opinion in chemical biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us