Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

9.8K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.8K
Membrane Domains01:18

Membrane Domains

7.9K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
7.9K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

6.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
6.7K
COP Coated Vesicles00:59

COP Coated Vesicles

18.4K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.4K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

9.9K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
9.9K
Contact-dependent Signaling01:19

Contact-dependent Signaling

48.2K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
48.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caveolae mechanics in cellular functions and disease.

Nature reviews. Molecular cell biology·2026
Same author

Diffusing caveolin-1 scaffolds regulate mechanosignalling.

Nature cell biology·2026
Same author

Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes.

Nature communications·2026
Same author

Retraction Note: Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1.

Virology journal·2026
Same author

DAB2 in LGMD R2: a molecular link between disease progression and lipid dysregulation.

JCI insight·2026
Same author

Editorial: Reviews and advances on the role of membrane trafficking in cancer.

Frontiers in cell and developmental biology·2025

Related Experiment Video

Updated: Feb 27, 2026

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

8.4K

The caveolae dress code: structure and signaling.

Christophe Lamaze1, Nicolas Tardif1, Melissa Dewulf1

  • 1Institut Curie - Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143, Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, 75248 Paris cedex 05, France.

Current Opinion in Cell Biology
|June 23, 2017
PubMed
Summary

Caveolae, vital cell organelles, are now understood as complex signaling hubs. Recent discoveries illuminate their protein coat structure, advancing our knowledge of cellular functions and diseases.

More Related Videos

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.9K
Measuring Fast Calcium Fluxes in Cardiomyocytes
12:10

Measuring Fast Calcium Fluxes in Cardiomyocytes

Published on: November 29, 2011

15.9K

Related Experiment Videos

Last Updated: Feb 27, 2026

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

8.4K
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.9K
Measuring Fast Calcium Fluxes in Cardiomyocytes
12:10

Measuring Fast Calcium Fluxes in Cardiomyocytes

Published on: November 29, 2011

15.9K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Caveolae are small, bulb-shaped invaginations of the plasma membrane (50-80nm diameter) found in most cell types.
  • Initially considered simple membrane structures, caveolae are now recognized as complex organelles involved in essential cellular functions and various pathologies.
  • Despite their importance, the precise molecular mechanisms governing caveolae function remain incompletely understood.

Purpose of the Study:

  • To review recent advancements in understanding caveolae biology, focusing on their structural organization.
  • To integrate new data on caveolae coat constituents (caveolins and cavins) with their roles in cellular signaling.
  • To discuss the implications of these findings for understanding caveolae-related pathophysiology.

Main Methods:

  • Literature review of recent studies on caveolae biology.
  • Analysis of research identifying caveolins and cavins as key structural components.
  • Synthesis of data linking caveolae structure to signaling pathways and disease.

Main Results:

  • Caveolae are confirmed as bona fide organelles with sophisticated structural organization.
  • Caveolins and cavins have been identified as the primary constituents forming the caveolae coat.
  • Emerging evidence highlights caveolae's critical role in cellular signal transduction.

Conclusions:

  • Recent insights into caveolae structure, particularly the caveolin-cavins coat, provide a framework for understanding their function.
  • Further research integrating structural and functional data is crucial for elucidating caveolae's role in signaling and disease.
  • Understanding caveolae mechanisms is key to addressing associated pathologies.