Clinically Relevant Biomarkers in Acute Heart Failure: An Update

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Agnibh Mukherji1, Uzair Ansari1, Martin Borggrefe1

  • 1First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Mannheim. Germany.

Current Pharmaceutical Biotechnology
|June 24, 2017
PubMed

Insights

Novel biomarkers show promise for diagnosing and managing acute heart failure (AHF). Further research into emerging markers like osteopontin could improve patient outcomes and risk stratification.

Area of Science:

  • Cardiology
  • Biomarker Research

Background:

  • Acute Heart Failure (AHF) presents significant challenges in diagnosis, prognosis, and management, contributing to high morbidity and mortality.
  • Novel biomarkers beyond natriuretic peptides are emerging, offering new hope for improved AHF assessment.

Purpose of the Study:

  • To review the current landscape of cardiac biomarkers for Acute Heart Failure (AHF).
  • To highlight established and emerging biomarkers for AHF diagnosis, risk stratification, and comorbidity evaluation.

Main Methods:

  • Comprehensive literature review of recent articles, expert reviews, textbooks, and guidelines.
  • Inclusion of data from the latest clinical trials on AHF biomarkers.
  • Selection of the most relevant biomarkers for detailed discussion.

Main Results:

  • Established biomarkers like midregional proatrial natriuretic peptide, soluble ST2, highly-sensitive troponin, and midregional proadrenomedullin are validated for AHF.
  • Emerging biomarkers such as osteopontin, CTGF, GDF-15, and TGF beta-1 require further investigation.
  • Biomarkers for comorbidities (PCT, hematologic markers) and acute kidney injury (NGAL) offer new management perspectives.

Conclusions:

  • This review summarizes the current status and relevance of key cardiac biomarkers in Acute Heart Failure (AHF).
  • The findings underscore the evolving role of biomarkers in refining AHF diagnosis and patient management.
Abstract

Keywords:
Acute heart failureCTGFmyocardial injurymyocardial remodeling markersnatriuretic peptidesneurohormonal activation markers

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