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Substance Use Disorders Affecting Sleep01:24

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
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Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
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Related Experiment Video

Updated: Feb 27, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
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Try to Remember: Interplay between Memory and Substance Use Disorder.

Rashidi Mohamed Pakri Mohamed1, Jaya Kumar2, Ernie Yap3

  • 1Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.

Current Drug Targets
|June 24, 2017
PubMed
Summary
This summary is machine-generated.

Substance use disorder memories can be weakened by targeting synaptic plasticity and unique neurobiological pathways. Novel drugs show preclinical promise in reducing cravings and relapse by intervening in memory formation.

Keywords:
AddictionPKM zetablebbistatincueisradipinememoryrelapse.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Substance use disorder (SUD) is characterized by memories that trigger craving and relapse.
  • Synaptic plasticity manipulation is a potential strategy to weaken these substance-associated memories.
  • Emerging research suggests unique neurobiological pathways for SUD memories, offering pharmacological intervention targets.

Purpose of the Study:

  • To review the evolving understanding of biochemical mechanisms in memory formation.
  • To explore the premise that SUD is a learning disorder.
  • To highlight potential pharmacological interventions for SUD-related memories.

Main Methods:

  • Review of current literature on neurochemistry and memory formation.
  • Analysis of preclinical data on candidate molecules and drugs.
  • Discussion of neurobiological pathways implicated in substance abuse.

Main Results:

  • Identification of neurochemical targets influencing long-term memory formation and maintenance.
  • Preclinical promise of drugs like blebbistatin, isradipine, and zeta inhibitory peptide.
  • Evidence supporting the accessibility of SUD memories for pharmacological intervention.

Conclusions:

  • Substance use disorder can be conceptualized as a learning disorder.
  • Targeting specific neurobiological and biochemical mechanisms offers a promising avenue for treating SUD.
  • Pharmacological interventions hold potential for reducing relapse by modifying substance-associated memories.