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Related Experiment Videos

LSD Detection and Interpretation in Hair.

Camille Richeval1,2, Delphine Allorge1,2, Xavier Vanhoye1

  • 1CHU Lille, Unité Fonctionnelle de Toxicologie, F-59000 Lille, France.

Current Pharmaceutical Design
|June 24, 2017
PubMed
Summary

Analyzing lysergic acid diethylamide (LSD) in hair presents challenges due to sparse data and potential contamination. Interpreting LSD hair test results for consumption or frequency remains uncertain.

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Area of Science:

  • Forensic Toxicology
  • Pharmacology
  • Analytical Chemistry

Background:

  • Lysergic acid diethylamide (LSD) is a potent hallucinogen requiring sensitive detection methods.
  • Low dosages of LSD present analytical challenges in clinical and forensic settings, particularly in biological matrices like hair.
  • Hair analysis for LSD is complicated by limited data and potential confounding factors.

Purpose of the Study:

  • To review existing literature on lysergic acid diethylamide (LSD) hair analysis.
  • To identify and discuss the primary challenges in detecting and interpreting LSD concentrations in hair samples.
  • To evaluate the reliability of hair testing for confirming LSD consumption and frequency.

Main Methods:

  • Literature review of studies reporting LSD detection in human hair.
Keywords:
LSDclinical toxicologyforensic toxicologyhair analysishead hairpubic hair

Related Experiment Videos

  • Analysis of reported LSD concentrations in hair samples.
  • Discussion of factors influencing LSD incorporation, stability, and detection in head and pubic hair.

    • Main Results:

    • Very limited data (n=10) exists on LSD concentrations in hair, making interpretation difficult.
    • Potential for pubic hair contamination from urine complicates results.
    • Lack of data on LSD incorporation and stability in hair hinders accurate interpretation.
    • Absence of LSD in head hair does not exclude consumption.
    • Interpreting positive LSD hair results for consumption frequency or distinguishing single vs. repeated use is uncertain.

    Conclusions:

    • Interpreting LSD hair analysis results is challenging due to sparse data and methodological limitations.
    • Positive LSD results in hair, especially pubic hair, cannot definitively confirm repeated use.
    • Further research is needed to establish reliable methods for LSD detection and interpretation in hair.