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Non-invasive Assessment of Microvascular and Endothelial Function
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Capillaroscopy in Routine Diagnostics: Potentials and Limitations.

Francesca Ingegnoli1, Vanessa Smith2, Alberto Sulli3

  • 1Division of Rheumatology, ASST Pini, Milano, Dept. of Clinical Sciences & Community Health, Universita degli Studi di Milano, Milano, Italy.

Current Rheumatology Reviews
|June 24, 2017
PubMed
Summary
This summary is machine-generated.

Nailfold capillaroscopy is a safe tool for early detection of microvascular issues in Raynaud

Keywords:
Nailfold capillaroscopyRaynaud's phenomenonautoantibodiesbiomarkersclassification criteriaconnective tissue diseasesdifferential diagnosisimagingmicrocirculationsystemic sclerosissystemic sclerosis.

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Diagnostic Imaging

Background:

  • Nailfold capillaroscopy is a valuable diagnostic tool for identifying microvascular abnormalities.
  • It is particularly useful in patients with Raynaud's phenomenon secondary to scleroderma-spectrum disorders.
  • Its role in diagnosing systemic sclerosis is well-established and included in classification criteria.

Purpose of the Study:

  • To highlight the utility of nailfold capillaroscopy in early disease detection.
  • To explore its potential in monitoring disease progression and treatment response.
  • To investigate its application in understanding the pathophysiology of scleroderma-spectrum disorders.

Main Methods:

  • Qualitative description of microvascular abnormalities using nailfold capillaroscopy.
  • Application in patients with Raynaud's phenomenon and scleroderma-spectrum disorders.
  • Inclusion in diagnostic criteria for systemic sclerosis.

Main Results:

  • Nailfold capillaroscopy enables early detection and qualitative description of microvascular abnormalities.
  • It is a key investigation in the early phases of systemic sclerosis.
  • Potential insights into pathophysiology of microvascular components in related disorders.

Conclusions:

  • Nailfold capillaroscopy is a safe and effective tool for early diagnosis.
  • It aids in monitoring disease progression and treatment response in systemic sclerosis.
  • Its application offers new insights into the pathophysiology of associated microvascular diseases.