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Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?

Savas Topuk1, Yener Akyuva2, Numan Karaaslan3

  • 1Department of Radiation Oncology, Cumhuriyet University School of Medicine, 58140, Sivas, Turkey.

Current Pharmaceutical Biotechnology
|June 24, 2017
PubMed
Abstract

Insights

Experimental osteosarcoma treatments using novel drug delivery systems are not yet clinically ready. While controlled release of small interfering/micro ribonucleic acid shows promise, successful integration remains a challenge.

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Molecular Biology

Background:

  • Osteosarcoma remains a significant challenge in bone cancer treatment.
  • Targeted therapies, including those using ribonucleic acid (RNA) interference, are under investigation.
  • Drug delivery systems are crucial for effective RNA-based therapies.

Purpose of the Study:

  • To review experimental research on drug delivery systems for osteosarcoma treatment.
  • To analyze systems incorporating small interfering RNA (siRNA) and micro RNA (miRNA).
  • To assess the clinical readiness of these advanced therapeutic approaches.

Main Methods:

  • Comprehensive literature search of major biomedical databases (PubMed, Embase, Ovid, Cochrane).
  • Inclusion of studies from 1843 to May 2016, with no language restrictions.
  • Data analysis using descriptive statistics to summarize findings.

Main Results:

  • No studies reported successful embedding of siRNA/miRNA oligonucleotides in drug delivery systems for osteosarcoma.
  • Only one study utilized hairpin-RNA in an experimental delivery system.
  • Current systems are not projected for clinical application in osteosarcoma treatment.

Conclusions:

  • Drug delivery systems for controlled oligonucleotide release in osteosarcoma are not yet clinically viable.
  • Experimental studies provide a foundation for future targeted therapies.
  • RNA-based approaches hold future promise for effective osteosarcoma treatment.
Keywords:
Controlled releasedrug delivery systemsmiRNAosteosarcomapharmacogenomicssiRNA

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