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Related Experiment Video

Updated: Feb 27, 2026

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Subventricular Zone Involvement Characterized by Diffusion Tensor Imaging in Glioblastoma.

Bart R J van Dijken1, Jiun-Lin Yan2, Natalie R Boonzaier3

  • 1Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

World Neurosurgery
|June 24, 2017
PubMed
Summary

Diffusion tensor imaging (DTI) reveals glioblastoma infiltration into the subventricular zone. This finding highlights the subventricular zone

Keywords:
Diffusion tensor imagingGlioblastomaMagnetic resonance imagingNeural stem cellsSubventricular zone

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Area of Science:

  • Neuroimaging
  • Oncology
  • Radiology

Background:

  • Glioblastomas have a poor prognosis, often linked to therapy-resistant stem cells.
  • The subventricular zone is a primary source of neural stem cells.
  • Understanding subventricular zone involvement in glioblastoma is crucial.

Purpose of the Study:

  • To characterize the subventricular zone using diffusion tensor imaging (DTI).
  • To demonstrate subventricular zone involvement in glioblastoma.
  • To investigate potential glioblastoma stem cell niches.

Main Methods:

  • Prospective inclusion of 93 primary glioblastoma patients undergoing preoperative DTI.
  • Definition of subventricular zone (SVZ) using a 5-mm margin around lateral ventricles.
  • Comparison of DTI parameters in SVZ with high FLAIR signal versus controls.

Main Results:

  • Increased isotropic p values in the SVZ with high FLAIR signal compared to controls (P < 0.001).
  • Lower anisotropic q and fractional anisotropy values in high FLAIR SVZ regions (P < 0.001).
  • DTI parameters indicate microstructural changes consistent with tumor infiltration.

Conclusions:

  • DTI data confirms subventricular zone involvement in glioblastoma.
  • Elevated isotropic p values in the high FLAIR SVZ suggest tumor infiltration.
  • Findings may have implications for understanding glioblastoma stem cell behavior.