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[Local antibiotic therapy].

Klaus-Dieter Kühn1, Nora Renz2, Andrej Trampuz2

  • 1Universitätsklinik für Orthopädie und Orthopädische Chirurgie, Medizinische Universität Graz, Auenbruggerplatz 5, 8036, Graz, Österreich. Klaus.kuehn@medunigraz.at.

Der Unfallchirurg
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Summary
This summary is machine-generated.

Local antibiotics are crucial for preventing biofilm formation and treating implant-associated infections, especially when combined with systemic approaches. Polymethylmethacrylate bone cement is a key local drug carrier for effective treatment.

Keywords:
BiofilmColonization barrierManual applicationPMMA cementRecommendations

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Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Biomaterials

Background:

  • Superficial wound infections treated with local antibiotics risk resistance and ineffectiveness.
  • Implant-associated infections require a combined systemic and local antibiotic approach due to biofilm formation and pathogen resistance.
  • Necrotic tissue and implants create reservoirs for pathogens, complicating bone and joint infection treatment.

Purpose of the Study:

  • To review the principles and considerations for the local application of antibiotics in implant-associated infections.
  • To highlight the role of local antibiotic delivery in preventing biofilm formation on implants.
  • To discuss the use of polymethylmethacrylate (PMMA) bone cement as a local drug carrier.

Main Methods:

  • Literature review of systemic and local antibiotic applications in orthopedic infections.
  • Analysis of antibiotic penetration and efficacy in bone and around implants.
  • Evaluation of polymethylmethacrylate (PMMA) bone cement as a drug delivery system.

Main Results:

  • Local antibiotic application is effective in preventing biofilm on implants and treating associated infections.
  • Systemic antibiotics have limitations in bone penetration, making local delivery essential for implant colonization.
  • Polymethylmethacrylate (PMMA) bone cement is a widely used and effective carrier for local antibiotic delivery.

Conclusions:

  • A combined systemic and local antibiotic strategy is vital for successful treatment of implant-associated infections.
  • Careful selection of antibiotics for local PMMA cement application, guided by experts, is critical.
  • Further research and clear guidelines are needed for optimal local antibiotic strategies in orthopedic surgery.