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Coronary microvascular dysfunction in diabetes mellitus

Aleksandar Kibel1,2, Kristina Selthofer-Relatic1,3, Ines Drenjancevic2

  • 11 Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia.

The Journal of International Medical Research
|June 24, 2017
PubMed

Insights

Diabetes mellitus significantly impacts coronary microvascular function, leading to complications. Further research is needed to understand the mechanisms and consequences of this dysfunction in the heart

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Microcirculation Research

Background:

  • Diabetes mellitus is linked to endothelial dysfunction across vascular beds, affecting microcirculatory regulation.
  • The coronary microcirculation is vital for matching blood flow to myocardial metabolic needs.
  • Dysregulation of coronary microcirculation in diabetes can lead to pathological consequences.

Purpose of the Study:

  • To review current knowledge on coronary microvascular dysfunction in diabetes mellitus.
  • To explore the significance, mechanisms, and consequences of this condition.
  • To synthesize findings from pre-clinical and clinical studies.

Main Methods:

  • Literature review of pre-clinical research.
  • Analysis of clinical studies and patient data.
  • Synthesis of existing knowledge on diabetes-related cardiovascular complications.

Main Results:

  • Coronary microvascular dysfunction is a recognized complication of diabetes.
  • Endothelial dysfunction plays a key role in diabetes-induced microcirculatory issues.
  • Insufficient insight exists regarding the precise mechanisms and full consequences.

Conclusions:

  • Coronary microvascular dysfunction is a significant concern in diabetes mellitus.
  • Further investigation into mechanisms and clinical impact is warranted.
  • Understanding this dysfunction is crucial for managing diabetic cardiovascular complications.

Keywords:
Diabetes mellitusarachidonic acid metabolitesarterycardiomyopathycoronary microvascular dysfunctionendothelial dysfunctionmicrocirculationnitric oxide

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