Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fight retinoblastoma India: A decade of collective action, collaboration, and patient-centered care.

Indian journal of ophthalmology·2026
Same author

Lacrimal gland myoepithelial carcinoma ex pleomorphic adenoma with temporal fossa extension and pulmonary metastasis.

Orbit (Amsterdam, Netherlands)·2026
Same author

Intraocular seeds in retinoblastoma: A review of classification, management, and outcomes.

Survey of ophthalmology·2025
Same author

Survival outcomes and globe salvage rates of retinoblastoma in India - A systematic review.

Indian journal of ophthalmology·2025
Same author

Lag time for diagnosis and treatment in 1120 retinoblastoma children: Analysis from InPOG-RB-19-01.

Indian journal of ophthalmology·2025
Same author

Brachytherapy for Aggressive Conjunctival Inflammatory Myofibroblastic Tumor.

Ophthalmology·2025

Related Experiment Video

Updated: Feb 27, 2026

Reconstruct Human Retinoblastoma In Vitro
06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

1.8K

Orbital retinoblastoma: An update.

Santosh G Honavar1, Fairooz P Manjandavida2, Vijay Anand P Reddy1

  • 1Centre for Sight, Hyderabad, Telangana, India.

Indian Journal of Ophthalmology
|June 24, 2017
PubMed
Summary

Orbital extension in retinoblastoma is deadly in developing nations. Sequential multimodal therapy significantly improves survival rates, overcoming limitations of conventional treatments.

Area of Science:

  • Pediatric Oncology
  • Ophthalmology
  • Cancer Research

Background:

  • Orbital extension of retinoblastoma is a primary cause of mortality in children, particularly in developing countries.
  • Delayed diagnosis and inadequate treatment strategies contribute to high mortality rates.
  • Conventional therapies like surgery, chemotherapy, or radiotherapy alone yield poor outcomes with up to 70% mortality.

Purpose of the Study:

  • To highlight the critical impact of orbital extension in retinoblastoma.
  • To emphasize the inadequacy of conventional single-modality treatments.
  • To present sequential multimodal therapy as a superior approach for improving survival.

Main Methods:

  • Review of treatment outcomes for retinoblastoma with orbital extension.

More Related Videos

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.2K

Related Experiment Videos

Last Updated: Feb 27, 2026

Reconstruct Human Retinoblastoma In Vitro
06:52

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

1.8K
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
07:55

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

12.2K
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.2K
  • Analysis of conventional treatment modalities (exenteration, chemotherapy, radiotherapy).
  • Evaluation of sequential multimodal therapy protocols.

    • Main Results:

    • Conventional treatments result in mortality rates as high as 70%.
    • Sequential multimodal therapy, combining high-dose chemotherapy, surgery, radiotherapy, and adjuvant chemotherapy, shows improved life salvage.
    • This integrated approach addresses the complexities of advanced retinoblastoma.

    Conclusions:

    • Sequential multimodal therapy represents a significant advancement in managing orbital retinoblastoma.
    • Improved life salvage is achievable through a comprehensive, multi-step treatment strategy.
    • This approach is crucial for improving outcomes in resource-limited settings.