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Updated: Feb 27, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Deep sclerectomy for uveitic glaucoma: long-term outcomes.

K Mercieca1,2, L Steeples1,2, N Anand3

  • 1Manchester Royal Eye Hospital, Manchester, UK.

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|June 24, 2017
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Deep sclerectomy (DS) effectively lowers intraocular pressure (IOP) in uveitic glaucoma patients long-term. While safe, some patients may require additional IOP-lowering procedures over time.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Interventions

Background:

  • Uveitic glaucoma presents unique challenges due to intraocular inflammation.
  • Elevated intraocular pressure (IOP) in uveitic glaucoma requires effective long-term management.
  • Previous intraocular surgeries are common in patients with uveitic glaucoma.

Purpose of the Study:

  • To evaluate the long-term efficacy and safety of deep sclerectomy (DS) for managing uveitic glaucoma.
  • To assess the impact of DS on intraocular pressure (IOP) and medication requirements in this patient population.
  • To identify potential complications and the need for subsequent interventions after DS.

Main Methods:

  • Retrospective analysis of 43 eyes from 43 patients diagnosed with uveitic glaucoma.
  • Deep sclerectomy (DS) performed, with Mitomycin C (MMC) application in 81% of cases.
  • Combined phacoemulsification and DS in 9% of cases; mean follow-up of 68.5 months.

Main Results:

  • Mean preoperative IOP of 33.6 mmHg decreased significantly post-surgery, with sustained IOP reduction at 1, 3, and 5 years.
  • High probability of IOP <22 mmHg (69%) and <19 mmHg (62%) at 3 years, and (60%) and (51%) at 5 years, respectively.
  • Significant reduction in glaucoma medications from 3.0 to 0.8; 16.3% required further IOP-lowering procedures.

Conclusions:

  • Deep sclerectomy (DS) is a safe and effective surgical option for lowering IOP in uveitic glaucoma.
  • Long-term IOP control is achievable, though a proportion of patients may need further interventions.
  • DS offers a valuable therapeutic approach, but careful monitoring for recurrence of uveitis and IOP management is essential.