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Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
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Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
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Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
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Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
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Extensive horizontal gene transfer in cheese-associated bacteria.

Kevin S Bonham1, Benjamin E Wolfe2, Rachel J Dutton1,3

  • 1Division of Biological Sciences, University of California, San Diego, San Diego, United States.

Elife
|June 24, 2017
PubMed
Summary
This summary is machine-generated.

Horizontal gene transfer (HGT) helps microbes adapt. In cheese rinds, widespread HGT regions were identified, revealing key genes for adaptation and microbiome assembly.

Keywords:
CheeseHorizontal Gene TransferMicrobial communitiesModel systems for microbial communitiesSiderophoresevolutionary biologygenomicsinfectious diseasemicrobiology

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Area of Science:

  • Microbiology
  • Genomics
  • Microbiome research

Background:

  • Horizontal gene transfer (HGT) is a key mechanism for microbial adaptation.
  • Identifying HGT regions aids understanding of microbiome assembly.

Purpose of the Study:

  • To identify horizontally transferred genes in a model microbiome: the cheese rind.
  • To pinpoint molecular mechanisms driving microbiome assembly through HGT.

Main Methods:

  • Comparative genomics of bacterial isolates from cheese rinds.
  • Sequencing and analysis of 31 new and 134 existing bacterial isolates.

Main Results:

  • Over 200 putative horizontally transferred genomic regions identified, containing 4733 protein-coding genes.
  • Largest HGT regions are enriched for siderophore acquisition genes.
  • These regions are prevalent in European and US cheese rind microbiomes.

Conclusions:

  • Horizontal gene transfer is a significant force in shaping cheese rind microbiomes.
  • Frequently transferred genes offer insights into environmental selective pressures on microbial communities.