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Updated: Feb 27, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Platelet pathophysiology, pharmacology, and function in coronary artery disease
Homam Ibrahim1, Neal S Kleiman
1aDepartment of Cardiology, New York Langone Medical Center, New York, New York bDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Abstract:
Platelets play a key role in the pathophysiology of coronary artery disease and acute coronary syndromes. Our understanding of platelet function in thrombus formation has increased considerably, resulting in the development of clinically effective treatment strategies and identification of new targets. An underappreciated platelet function is their contribution toward acute and chronic inflammatory processes including atherogenesis. In this review, we discuss the role of platelets in atherosclerosis and thrombosis, platelet function testing, and the pharmacology of currently available antiplatelet drugs.
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