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Updated: Feb 27, 2026

Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC
Carmen Fiuza-Luces1, Julio R Padilla, Jaime Valentín
1From the Research Institute of the Hospital '12 de Octubre' (i+12), Madrid, Spain (CF-L, ES-S, AS-L, FS-G, HP-G, A. Lucia); Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain (CF-L); European University, Madrid, Spain (JRP, ES-S, HP-G, JSM, MP, A. Lucia); Innate Immune Research Group, IdiPAZ, Madrid, Spain (JV); i+HeALTH Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain (AS-L); Department of Physiology, Faculty of Medicine, University of Valencia and Fundación de Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain (FS-G); Andrews Research and Education Foundation, Gulf Breeze, Florida (SJF); Department of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital Niño Jesús, Madrid, Spain (A. Lassaletta); Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal (LS-M); and Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, University Hospital La Paz, Madrid, Spain (AP-M).
Abstract:
The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive nature.
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