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Updated: Feb 27, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Methods for the detection and identification of pathogenic bacteria: past, present, and future
Linda Váradi1, Jia Lin Luo, David E Hibbs
1Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia. paul.groundwater@sydney.edu.au.
Abstract:
In order to retard the rate of development of antibacterial resistance, the causative agent must be identified as rapidly as possible, so that directed patient treatment and/or contact precautions can be initiated. This review highlights the challenges associated with the detection and identification of pathogenic bacteria, by providing an introduction to the techniques currently used, as well as newer techniques that are in development. Focusing on the chemical basis for these techniques, the review also provides a comparison of their advantages and disadvantages.
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