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Updated: Feb 27, 2026

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Published on: October 31, 2019
Bacteria and the Fate of Estrogen in the Environment
1Department of Microbiology, University of Georgia, Athens, GA 30602-2605, USA.
Abstract:
In this issue of Cell Chemical Biology, Chen et al. (2017) report that 4-hydroxyestrone and pyridinestrone acid are intermediates in the 4,5-seco pathway of aerobic estrogen degradation by the bacterium Sphingomonas. The authors identify a gene for 4-hydroxyestrone 4,5-dioxygenase and find it to be widely distributed in diverse proteobacteria, suggesting that this pathway is environmentally significant.
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