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Updated: Feb 27, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Stereotactic Radiosurgery for Brainstem Arteriovenous Malformations: A Multicenter Study.

Or Cohen-Inbar1,2, Robert M Starke1, Cheng-Chia Lee3

  • 1Department of Neurosurgery and Gamma-Knife center, University of Virginia, Charlottesville, Virginia.

Neurosurgery
|June 25, 2017
PubMed
Summary
This summary is machine-generated.

Stereotactic radiosurgery (SRS) for brainstem arteriovenous malformations (bAVMs) leads to obliteration in most patients. This treatment effectively avoids permanent complications, offering a favorable outcome for the majority.

Keywords:
Arteriovenous malformationBrainstemEmbolizationGamma knifeHemorrhageOutcomeRadiosurgerySurgery

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Vascular Neurology

Background:

  • Brainstem arteriovenous malformations (bAVMs) present significant management challenges due to high associated morbidity and mortality.
  • Effective treatment strategies for bAVMs remain an area of critical clinical need.

Purpose of the Study:

  • To evaluate the outcomes of stereotactic radiosurgery (SRS) for brainstem arteriovenous malformations (bAVMs).
  • To identify factors influencing successful obliteration and favorable outcomes after SRS treatment for bAVMs.

Main Methods:

  • A multicenter retrospective study involving 205 patients treated with SRS for bAVMs.
  • Data collected from six institutions via the International Gamma Knife Research Foundation.
  • Favorable outcome (FO) defined as AVM obliteration without post-treatment hemorrhage or permanent symptomatic radiation-induced complications.

Main Results:

  • Overall obliteration rate was 65.4%, with 53.2% confirmed angiographically.
  • Actuarial obliteration rates reached 81.8% by 10 years post-SRS.
  • Favorable outcomes were achieved in 64.4% of patients; higher SRS doses correlated with obliteration, while lower maximum doses predicted favorable outcomes.

Conclusions:

  • Stereotactic radiosurgery is an effective treatment for brainstem arteriovenous malformations, achieving obliteration in a majority of cases.
  • SRS for bAVMs can lead to favorable outcomes, with careful dose selection being a key factor.