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Salmonella virulence plasmid: pathogenesis and ecology
Claudia Silva1, José Luis Puente1, Edmundo Calva1
1Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico.
Pathogens and Disease
|June 25, 2017
Summary
The Salmonella virulence plasmid plays a key role in host pathogenesis and survival in diverse environments. Further research using the One Health approach is crucial for understanding Salmonella
Area of Science:
- Microbiology
- Infectious Diseases
- Veterinary Medicine
Background:
- The Salmonella virulence plasmid (pVS) is a critical factor in bacterial pathogenesis.
- Understanding its role in both primary hosts and secondary ecological niches is essential.
Purpose of the Study:
- To review the current understanding of the Salmonella virulence plasmid's role in pathogenesis.
- To explore its relevance in secondary ecological niches.
- To propose future research strategies within the One Health framework.
Main Methods:
- Literature review and synthesis of current research on Salmonella pathogenesis.
- Analysis of the plasmid's contribution to host-pathogen interactions.
- Conceptualization of One Health-aligned research approaches.
Main Results:
- The Salmonella virulence plasmid significantly impacts disease development in animal and human hosts.
- Evidence suggests the plasmid may confer advantages for survival in various ecological settings.
- The review highlights knowledge gaps regarding the plasmid's extrachromosomal role.
Conclusions:
- The Salmonella virulence plasmid is a crucial determinant of disease.
- Its role in environmental survival warrants further investigation.
- Adopting a One Health perspective is vital for comprehensive Salmonella control strategies.
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