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Degenerative changes of the canine cervical spine after discectomy procedures, an in vivo study
Peter Grunert1,2, Yu Moriguchi1, Brian P Grossbard3
1Department of Neurological Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, Weill Cornell Brain and Spine Institute|, 525 East 68th Street, Box 99, New York, NY, 10065, USA.
Background:
Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo.
Results:
Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis. MR imaging revealed terminal degenerative changes with collapse of the disc space and loss of T2 signal intensity. The endplates showed degenerative type II Modic changes. Quantitative MR imaging revealed that over 95% of Nucleus Pulposus tissue was extracted and that the nuclear as well as overall disc hydration significantly decreased. Histology confirmed terminal degenerative changes with loss of NP tissue, loss of Annulus Fibrosus organization and loss of cartilage endplate tissue. The bony endplate displayed sclerotic changes.
Conclusion:
Discectomies lead to terminal degenerative changes. Therefore, these procedures should be indicated with caution specifically when performed for prophylactic purposes.
