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Updated: Feb 27, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Titration technique using endoscopy for an oral appliance treatment of obstructive sleep apnea
Kentaro Okuno1, Kazuki Ikai2, Erika Matsumura-Ai3
1Fellow, Division of Functional Oral Neuroscience, Osaka University Graduate School of Dentistry, Osaka, Japan.
Abstract:
The degree of mandibular protrusion for an oral appliance (OA) should be customized for each patient with obstructive sleep apnea (OSA). This article describes the mandibular titration technique for OAs to effectively treat OSA by using endoscopy to evaluate the change in the airway at the velopharynx. This technique may minimize the degree of mandible protrusion and contribute to both the efficacy of and compliance with OA therapy.
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