Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Global Consensus Conference on Surgical Management of Primary Uterovaginal Prolapse and Lower Urinary Tract Dysfunction: Combining Evidence with Expert Opinion.

International urogynecology journal·2026

Same author

Radiofrequency-induced heating safety of brain MRI scans at 7 T in the presence of a shoulder implant.

Magnetic resonance imaging·2026

Same author

Management of Persistent Storage Symptoms and Overactive Bladder in Men Diagnosed with Benign Prostatic Hyperplasia: A Narrative Review.

Advances in therapy·2026

Same author

Unequal Utilization of Overactive Bladder Treatment: The Role of Socioeconomic and Insurance Disparities.

Neurourology and urodynamics·2026

Same author

Patients' Perspectives and Challenges with Sacral Neuromodulation Implantable Pulse Generator.

International urogynecology journal·2026

Same author

Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence.

Nature reviews. Urology·2026

Same journal

On the Memoryless Property in Markov Models for NMIBC Cost-Effectiveness Analysis.

The Journal of urology·2026

Same journal

Multi-institutional Assessment of Performance Metrics for MRI-targeted Transperineal Prostate Biopsy.

The Journal of urology·2026

Same journal

Urinary Supersaturation in a Randomized Trial among Individuals with Recurrent Nephrolithiasis comparing Empiric versus Selective Preventive Therapy: The URINE Trial.

The Journal of urology·2026

Same journal

The FDA Should Allow More BCG Strains into the US Market: How Recent Landmark Trials Expose a Regulatory Paradox.

The Journal of urology·2026

Same journal

Let's Shift the Focus from Death to Life after Fournier's Gangrene.

The Journal of urology·2026

Same journal

Endourology and Nephrolithiasis.

The Journal of urology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

Real-Time Changes in Brain Activity during Sacral Neuromodulation for Overactive Bladder.

Bradley C Gill¹, Javier Pizarro-Berdichevsky², Pallab K Bhattacharyya³

¹Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio; Lerner College of Medicine, Education Institute, Cleveland Clinic, Cleveland, Ohio; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

The Journal of Urology

|June 25, 2017

Summary

This summary is machine-generated.

Sacral neuromodulation (SNM) alters brain activity in women with overactive bladder (OAB) who respond to therapy. Brain activation patterns change with varying SNM stimulation intensity, confirming its neurological effects.

Keywords:

brain mapping implantable neurostimulators magnetic resonance imaging overactive surveys and questionnaires urinary bladder

More Related Videos

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Published on: January 19, 2024

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Feb 27, 2026

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

Published on: July 11, 2025

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Published on: January 19, 2024

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Area of Science:

Neuroscience
Urology
Medical Imaging

Background:

Overactive bladder (OAB) is a common condition affecting quality of life.
Sacral neuromodulation (SNM) is an effective treatment for refractory OAB.
Understanding the neural mechanisms of SNM is crucial for optimizing treatment.

Purpose of the Study:

To investigate brain activity changes during SNM in women with OAB who responded to therapy.
To correlate brain activation patterns with different SNM stimulation intensities.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to map brain activity.
Three fMRI scans were performed at subsensory, sensory, and suprasensory stimulation levels.
Patients with refractory OAB who were responsive to SNM were included.

Main Results:

SNM influenced brain activity in women with OAB.
Brain activation generally increased with stimulation amplitude.
Specific brain regions like the insula, pons, and parietal lobes showed varied responses to different stimulation levels.

Conclusions:

fMRI confirmed SNM's impact on brain activity in OAB patients.
The observed brain changes varied significantly with stimulus intensity, highlighting the importance of personalized stimulation settings.