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Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients

H T Nacaroglu1, O B Gayret2, M Erol2

  • 1Bagcilar Training and Research Hospital, Pediatric Allergy and Immunology, Istanbul, Turkey.

Allergologia Et Immunopathologia
|June 25, 2017
PubMed

Insights

Obesity may not significantly alter key inflammation biomarkers in children with asthma. However, further research is needed to explore potential links between lung function and specific inflammatory markers in this population.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Obesity Research

Background:

  • Airway inflammation is often more challenging to manage in obese individuals with asthma.
  • Obesity may exacerbate asthma severity due to altered inflammatory responses and reduced treatment efficacy.

Purpose of the Study:

  • To examine the impact of obesity on airway and systemic inflammation in pediatric asthma patients.
  • To identify potential biomarkers associated with inflammation in obese children with asthma.

Main Methods:

  • Compared complete blood count parameters and inflammatory markers (hs-CRP, NGAL, OPN, MMP-9, 25(OH)-vitamin D) in three groups: obese asthmatic, obese non-asthmatic, and non-obese non-asthmatic children (ages 6-16).

Main Results:

  • No significant differences in 25(OH)-vitamin D, NGAL, OPN, hs-CRP, or MMP-9 levels were found between the groups.
  • A significant negative correlation was observed between FEV1/FVC ratio and NGAL and MMP-9 levels.

Conclusions:

  • This study is the first to assess hs-CRP, NGAL, OPN, MMP-9, and 25(OH)-vitamin D in obese pediatric asthma patients.
  • Larger studies incorporating sputum and bronchoalveolar lavage (BAL) are recommended to fully elucidate the role of these biomarkers in obese asthmatic children.
Abstract

Keywords:
25(OH)-vitamin DAsthmaChildhoodHigh-sensitive CRPMatrix metalloproteinase-9Neutrophil gelatinase-associated lipocalinObesityOsteopontin

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