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Updated: Feb 27, 2026

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells
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A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq.

Bin Li1,2, Tao Qing1,2, Jinhang Zhu1

  • 1Center for Pharmacogenomics, School of Pharmacy, and State Key Laboratory of Genetic Engineering, School of Life Sciences and Shanghai Cancer Hospital/Cancer Institute, Fudan University, Shanghai, 200438, China.

Scientific Reports
|June 25, 2017
PubMed
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This summary is machine-generated.

This study maps mouse gene expression across 17 tissues, identifying tissue-specific genes and 27 reference genes for expression analysis. The findings provide a valuable resource for biomedical research and drug development.

Area of Science:

  • Genomics
  • Transcriptomics
  • Biomedical Research

Background:

  • Mice are crucial model organisms for human disease research and drug development.
  • Tissue-specific gene expression influences disease and drug response.
  • Comprehensive transcriptomic data is needed for accurate analysis.

Purpose of the Study:

  • To create a comprehensive mouse transcriptomic BodyMap across 17 tissues.
  • To identify tissue-specific and housekeeping genes.
  • To propose reference genes for expression-profiling analysis.

Main Methods:

  • RNA sequencing (RNA-seq) was used to profile gene expression.
  • Data was collected from 17 different tissues of six-weeks old C57BL/6JJcl mice.
  • Analysis focused on protein-coding and non-coding gene expression patterns.

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Main Results:

  • Liver tissues showed the least complex transcriptomes, while testis and ovary were more complex.
  • A comprehensive list of tissue-specific genes was identified.
  • A list of 4,781 mouse housekeeping genes and 27 reference genes was generated.

Conclusions:

  • This study provides a valuable transcriptomic resource for mouse models.
  • The identified genes aid in understanding tissue specificity and gene regulation.
  • The proposed reference genes can improve the reliability of expression-profiling studies.