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Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Jan K Nowak1, Irena Wojsyk-Banaszak2, Edyta Mądry3

  • 1Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Lung
|June 25, 2017
PubMed

Insights

Cystic fibrosis (CF) patients have higher levels of soluble vascular cell adhesion molecule 1 (sVCAM-1) compared to healthy individuals. These elevated sVCAM-1 levels in CF are not explained by common CF characteristics, suggesting a potential link to cardiovascular health.

Area of Science:

  • Cardiovascular Health
  • Pulmonary Medicine
  • Biomarker Discovery

Background:

  • Increasing life expectancy in cystic fibrosis (CF) necessitates understanding its long-term impacts, including cardiovascular health.
  • Soluble vascular cell adhesion molecule 1 (sVCAM-1) and P-selectin (sP-selectin) are investigated as potential biomarkers for cardiovascular disease.
  • The study addresses the emerging questions about cardiovascular implications in the growing CF population.

Purpose of the Study:

  • To compare serum concentrations of sVCAM-1 and sP-selectin in clinically stable CF patients versus healthy subjects (HS).
  • To determine if sVCAM-1 and sP-selectin levels independently correlate with specific CF characteristics.
  • To investigate potential cardiovascular disease biomarkers in the context of CF.

Main Methods:

  • Serum sVCAM-1 and sP-selectin levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • CF patient characteristics included lung function (FEV1), pancreatic and liver disease status, Pseudomonas aeruginosa colonization, hsCRP, and BMI.
  • CFTR genotypes were categorized as severe (classes I/II) or other.

Main Results:

  • CF patients (n=108) exhibited significantly higher sVCAM-1 concentrations than HS (n=51) (p < 10⁻⁴).
  • No significant difference was observed in sP-selectin levels between CF patients and HS (p = 0.48).
  • Multivariable regression models could not validate the prediction of sVCAM-1 or sP-selectin based on CF characteristics.

Conclusions:

  • Elevated sVCAM-1 levels are present in CF patients compared to healthy individuals.
  • The observed increase in sVCAM-1 in CF is not attributable to known CF-related clinical parameters.
  • Further investigation is warranted to ascertain if sVCAM-1 serves as a marker for microangiopathy in cystic fibrosis.
Abstract

Keywords:
AtherogenesisAtherosclerosisCD106CD62GMP140LECAM3Pancreatic insufficiency

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