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Liver involvement in kidney disease and vice versa
Karen Van Hoeve1, Djalila Mekahli1,2, Eva Morava3
1Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium.
Pediatric Nephrology (Berlin, Germany)
|June 25, 2017
Summary
Pediatric liver and kidney diseases often share common causes, including metabolic, immunological, and toxic conditions. This review details pathogenic mechanisms and advocates for multidisciplinary care, with combined liver-kidney transplantation as a potential treatment.
Area of Science:
- Pediatric Nephrology
- Pediatric Hepatology
- Medical Genetics
Background:
- The liver and kidneys are frequently impacted concurrently by various diseases.
- Metabolic, immunological, toxic, infectious diseases, and congenital syndromes can affect both organs.
- Hepatic enzymatic defects or advanced liver disease can secondarily cause kidney disease.
Purpose of the Study:
- To review pathogenic mechanisms underlying liver and kidney dysfunction or malformations in children.
- To highlight the shared etiology of pediatric liver and kidney diseases.
- To emphasize the need for integrated patient management.
Main Methods:
- Literature review of pathogenic mechanisms.
- Analysis of shared disease pathways affecting liver and kidneys.
- Synthesis of current understanding of pediatric hepatorenal conditions.
Main Results:
- Numerous pathogenic mechanisms contribute to liver and kidney diseases in children.
- Shared underlying causes link hepatic and renal pathologies.
- Secondary kidney damage can arise from primary liver conditions.
Conclusions:
- Multidisciplinary management is crucial for optimal care of children with co-existing liver and kidney diseases.
- Understanding shared pathogenic mechanisms informs treatment strategies.
- Combined liver-kidney transplantation may be necessary in select pediatric cases.
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