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Updated: Feb 27, 2026
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
Fecal microbiota transplantation for recurrent clostridium difficile infection in children
Becky Chen1, Vishal Avinashi1, Simon Dobson2
1Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, Vancouver, BC, Canada.
Abstract:
Fecal microbiota transplantation (FMT) is a relatively simple, promising treatment for recurrent Clostridium difficile infection. While there are a wide variety of approaches including mode of delivery, the results are nonetheless encouraging, even amongst younger children. Experience with FMT in the pediatric population is increasing, showing similar success compared to adults. This article will provide an overview of C. difficile infection along with review of the rationale, methods and complications of FMT including the current experience of FMT in children.
Insights
Fecal microbiota transplantation (FMT) offers a promising treatment for recurrent Clostridium difficile infection in children. This approach shows encouraging success rates, similar to those observed in adults, with increasing pediatric experience.
Area of Science:
- Microbiology
- Gastroenterology
- Pediatric Medicine
Background:
- Recurrent Clostridium difficile infection (CDI) poses a significant health challenge.
- Fecal microbiota transplantation (FMT) is an emerging therapeutic option for refractory CDI.
- Pediatric experience with FMT is growing, with promising outcomes.
Purpose of the Study:
- To provide an overview of Clostridium difficile infection.
- To review the rationale, methods, and potential complications of FMT.
- To summarize the current evidence of FMT in pediatric patients.
Main Methods:
- Review of existing literature on FMT for CDI.
- Analysis of different FMT delivery methods.
- Evaluation of safety and efficacy data in pediatric populations.
Main Results:
- FMT demonstrates encouraging success rates for recurrent CDI.
- Treatment approaches vary, but outcomes are generally positive.
- Pediatric FMT outcomes appear comparable to adult outcomes.
Conclusions:
- FMT is a viable and effective treatment for pediatric recurrent CDI.
- Further research and standardized protocols for pediatric FMT are warranted.
- FMT represents a significant advancement in managing CDI in children.
