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Updated: Feb 27, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Neutrophils in cisplatin AKI-mediator or marker?
Raghu Tadagavadi1, W Brian Reeves2
1Janssen Research and Development, Johnson and Johnson, Spring House, Pennsylvania, USA.
Abstract:
Inflammation is an important mediator of most forms of acute kidney injury (AKI). Although neutrophils are prominent components of the inflammatory cascade, the precise role of neutrophils in AKI and the mechanisms by which they contribute to AKI remain controversial. In this issue, Deng et al. identify an important cross talk between renal epithelial cells and neutrophils involving the production and action of leukotriene B4 in mediating cisplatin AKI. We discuss the possible explanations for the discrepant findings that have been reported for neutrophils in cisplatin AKI.
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