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Related Experiment Video

Updated: Feb 27, 2026

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Targeting neuronal function for CNS drug discovery.

Chris M Hempel¹, Christopher A Werley¹, Graham T Dempsey¹

¹Q-State Biosciences, 179 Sidney Street, Cambridge, MA 02139, USA.

Drug Discovery Today. Technologies

|June 26, 2017

Summary

This summary is machine-generated.

New screening technologies and cellular models offer promising approaches for discovering central nervous system (CNS) disorder treatments by enabling phenotypic screening of neuronal function.

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Published on: August 16, 2010

Area of Science:

Neuroscience
Pharmacology
Drug Discovery

Background:

Central nervous system (CNS) disorders require novel therapeutic strategies.
Altered synaptic transmission and neuronal excitability are implicated in CNS diseases.
Traditional assay methods face challenges in targeting these complex neuronal functions.

Purpose of the Study:

To review advances in neuronal screening technologies.
To discuss cellular model systems for CNS drug discovery.
To highlight phenotypic screening of neuronal function.

Main Methods:

Review of current literature on neuronal screening technologies.
Analysis of cellular model systems for studying neuronal function.
Discussion of phenotypic screening approaches for CNS drug discovery.

Main Results:

Significant advancements in neuronal screening technologies have been made.
Novel cellular model systems facilitate the study of neuronal function.
Phenotypic screening offers a viable basis for CNS drug discovery.

Conclusions:

Advances in technology enable effective phenotypic screening of neuronal function.
New approaches are crucial for developing treatments for CNS disorders.
This review provides a foundation for future CNS drug discovery efforts.