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Bioprinted three dimensional human tissues for toxicology and disease modeling
Deborah G Nguyen1, Stephen L Pentoney1
1Organovo Inc., 6275 Nancy Ridge Dr., San Diego, CA 92121, United States.
Drug Discovery Today. Technologies
|June 26, 2017
Summary
Three-dimensional (3D) bioprinting creates advanced in vitro tissue models that better predict human biology. This technology improves drug development by enhancing the accuracy of toxicity and efficacy testing in preclinical research.
Area of Science:
- Biotechnology
- Tissue Engineering
- Toxicology
Background:
- High attrition rates in clinical trials stem from poor prediction of human toxicity and efficacy.
- Current in vitro models often fail to accurately recapitulate in vivo human biology.
Purpose of the Study:
- To provide an overview of commonly used three-dimensional (3D) bioprinting approaches.
- To highlight the application of 3D bioprinting in generating complex in vitro tissues for research.
Main Methods:
- Review of prevalent bioprinting techniques.
- Discussion of applications in creating advanced tissue models.
Main Results:
- Three-dimensional (3D) bioprinting enables automated production of in vitro tissue models.
- These models offer improved architectural and functional accuracy compared to traditional methods.
Conclusions:
- Three-dimensional (3D) bioprinting is a powerful tool for developing more predictive in vitro models.
- This technology can advance toxicology and disease modeling research, potentially reducing clinical trial attrition.
