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Updated: Feb 27, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Risk factors for lymph node metastases of facial cutaneous squamous cell carcinoma
Katharina Obermeier1, Matthias Tröltzsch1, Michael Ehrenfeld1
1Department of Oral & Maxillofacial Surgery (Head: Prof. Dr. Dr. M. Ehrenfeld), University of Munich, LMU, Germany.
Purpose:
Determining the risk factors for lymph node metastases of facial cutaneous squamous cell carcinoma and identifying their value for predicting nodal spread.
Material And Methods:
Data on 99 patients were examined retrospectively. Conditions such as tumor staging, tumor thickness, location, histological grading, R1-resection, local recurrence, lymph node metastases, and neurovascular and lymphovascular invasion were evaluated. Statistical analysis was performed using a logistic regression analysis and Fisher's test.
Results:
Logistic regression analysis indicates that poor differentiation, R1-resection, and periorbital location are high risk factors for nodal spread in facial cutaneous squamous cell carcinoma.
Conclusion:
Patients who show poorly differentiated facial cutaneous squamous cell carcinoma and/or have had previous R1-resection might benefit from treatment of regional lymph nodes.
