Bypass Surgery after Endovascular Therapy for Infrapopliteal Lesion Is Not a Poor Outcome Compared with Initial
Koichi Morisaki1, Terutoshi Yamaoka1, Kazuomi Iwasa1
1Department of Vascular Surgery, Matsuyama Red Cross Hospital, Matsuyama, Japan.
Insights
Bypass surgery after endovascular therapy (EVT) shows lower primary graft patency. However, limb salvage and survival rates remain unaffected by prior EVT in critical limb ischemia patients.
Area of Science:
- Vascular Surgery
- Endovascular Therapy
- Critical Limb Ischemia
Background:
- Prior endovascular therapy (EVT) impact on subsequent bypass surgery outcomes is unclear.
- Investigating treatment outcomes comparing bypass-first versus EVT-first strategies is crucial for critical limb ischemia (CLI) management.
Purpose of the Study:
- To compare outcomes of bypass surgery performed initially versus after prior EVT in CLI patients.
- To evaluate graft patency, limb salvage (LS), amputation-free survival (AFS), and overall survival (OS) between bypass-first and EVT-first groups.
Main Methods:
- Retrospective analysis of 75 patients (82 limbs) in bypass-first group and 24 patients (24 limbs) in EVT-first group undergoing infrapopliteal bypass (Nov 2006-Dec 2015).
- Comparison of primary patency, secondary patency, LS, AFS, and OS between the two groups.
Main Results:
- The EVT-first group had higher average age and a greater percentage of inframalleolar bypasses.
- Primary patency at 1 and 2 years was significantly lower in the EVT-first group (53.1%/47.2%) compared to the bypass-first group (72.0%/67.5%).
- Inframalleolar bypass was identified as a risk factor for lower primary patency; however, no significant differences were observed in secondary patency, LS, AFS, or OS.
Conclusions:
- Bypass surgery following EVT demonstrates reduced primary patency rates compared to primary bypass for infrapopliteal revascularization.
- Despite limitations and heterogeneity, previous EVT did not adversely affect limb salvage, overall survival, or amputation-free survival.
Background:
It is unclear whether prior endovascular therapy (EVT) adversely affects bypass surgery. The aim of this study is to investigate treatment outcomes between initial bypass (bypass-first) and bypass surgery after EVT (EVT-first).
Methods:
We conducted a retrospective analysis of critical limb ischemia patients undergoing infrapopliteal bypass between November 2006 and December 2015. Graft patency, limb salvage (LS), amputation-free survival (AFS), and overall survival (OS) were examined between bypass-first and EVT-first groups.
Results:
The subjects in this study were 75 patients and 82 limbs in the bypass-first group and 24 patients and 24 limbs in the EVT-first group. The average age was higher in EVT-first group (P = 0.03). The percentage of inframalleolar bypass was higher in the EVT-first group (P = 0.002). Primary patency at 1 and 2 years was 72.0% and 67.5% for the bypass-first group and 53.1% and 47.2% for the EVT-first group, respectively (P = 0.04). Inframalleolar bypass was a risk factor for lower primary patency (hazard ratio 3.07, 95% confidence interval 1.18-8.51, P = 0.02) in multivariate analysis, while there were no differences in secondary patency, LS, AFS, and OS.
Conclusions:
Bypass surgery after EVT has lower primary patency rates in comparison with primary bypass in patients submitted to infrapopliteal revascularization. Although very heterogeneous study population with a lot of bias in the indication of the revascularization, LS, OS and AFS are not affected by previous EVT.
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