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Hepatitis E virus and neurological disorders.

Brendan N Mclean1, James Gulliver2, Harry R Dalton2,3

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|June 26, 2017
PubMed
Summary
This summary is machine-generated.

Hepatitis E, often asymptomatic, is increasingly recognized in developed nations. This virus can cause serious neurological conditions like Guillain-Barré syndrome, prompting recommendations for broader testing.

Keywords:
Guillain-Barre SyndromeHepatitis EMeningoencephalitisNeuralgic Amyotropthy

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Neurology

Background:

  • Hepatitis E is a prevalent global liver infection, increasingly detected in developed countries.
  • Transmission is often linked to contaminated pork, with infections frequently asymptomatic.
  • Non-liver complications, particularly neurological manifestations, are increasingly recognized.

Purpose of the Study:

  • To highlight the emerging non-liver manifestations of Hepatitis E.
  • To emphasize the association between Hepatitis E and specific neurological disorders.
  • To recommend diagnostic strategies for Hepatitis E in patients with neurological symptoms.

Main Methods:

  • Review of current literature on Hepatitis E epidemiology and clinical presentations.
  • Analysis of reported cases linking Hepatitis E to neurological conditions.
  • Clinical recommendations based on observed associations.

Main Results:

  • Hepatitis E is associated with neurological conditions including Guillain-Barré syndrome (acute inflammatory demyelinating polyradiculoneuropathy (AIDP)), neuralgic amyotrophy, and meningoencephalitis.
  • These neurological manifestations are significant non-liver complications of Hepatitis E infection.
  • Asymptomatic infections can present with neurological symptoms.

Conclusions:

  • Testing for Hepatitis E should be considered in patients diagnosed with AIDP and neuralgic amyotrophy.
  • Patients presenting with unexplained neurological illness and abnormal liver function tests warrant Hepatitis E screening.
  • Increased awareness of Hepatitis E's neurological impact is crucial for timely diagnosis and management.