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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: Feb 27, 2026

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

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Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress.

Alan Bolnick^1,2, Awoniyi O Awonuga¹, Yu Yang^1,3

¹CS Mott Center for Human Growth and Development, Department of Ob/Gyn, Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, MI, 48201, USA.

Journal of Assisted Reproduction and Genetics

|June 26, 2017

Summary

Optimizing human blastocyst culture requires understanding stem cell responses to oxygen. This knowledge is crucial for improving in vitro fertilization (IVF) success rates in fertile women.

Keywords:

Blastocyst Hypoxic stress IVF Oxygen optimization Stem cells

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Published on: April 6, 2022

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

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Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

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Published on: June 12, 2020

Area of Science:

Reproductive biology
Stem cell physiology
In vitro fertilization (IVF)

Background:

Current debates exist regarding optimal oxygen levels for human blastocyst culture.
Previous studies have investigated 2% oxygen for blastocyst culture prior to embryo transfer.

Purpose of the Study:

To analyze the necessity of understanding stem cell physiology for blastocyst culture optimization.
To support the use of oxygen-response knowledge for enhancing IVF reproductive success.

Main Methods:

Literature review and analysis of existing research on blastocyst culture and oxygen.
Examination of stem cell responses to varying oxygen concentrations.

Main Results:

Understanding stem cell physiology is fundamental to optimizing blastocyst culture.
Oxygen's role in blastocyst development is a key factor for successful IVF outcomes.

Conclusions:

Further research into stem cell oxygen responses is needed for improved IVF protocols.
Optimized blastocyst culture conditions can enhance reproductive success.