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Related Experiment Video

Updated: Feb 27, 2026

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
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Are podocytes motile?

Nicole Endlich1,2, Florian Siegerist3, Karlhans Endlich3

  • 1Department of Anatomy and Cell Biology, University Medicine Greifswald, 17487, Greifswald, Germany. nicole.endlich@uni-greifswald.de.

Pflugers Archiv : European Journal of Physiology
|June 26, 2017
PubMed
Summary

Podocytes, crucial kidney cells, are not laterally motile in vivo. Recent studies show only dynamic apical protrusions occur under disease conditions, challenging previous assumptions about cell migration in kidney disease.

Keywords:
GlomerulusMotilityPodocyte

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Area of Science:

  • Nephrology
  • Cell Biology
  • Physiology

Background:

  • Podocytes are essential for the glomerular filtration barrier.
  • Their role in kidney disease pathogenesis is linked to their dynamic behavior.
  • Previous assumptions suggested podocyte motility in vivo.

Purpose of the Study:

  • To review recent findings on podocyte motility in vivo.
  • To investigate the dynamic behavior of podocytes under physiological and pathological conditions.
  • To clarify the role of different motility types in kidney diseases.

Main Methods:

  • In vivo microscopy techniques, including multiphoton microscopy.
  • Studies in living rodents and zebrafish larvae.
  • Analysis of podocyte behavior under physiological and pathological conditions.

Main Results:

  • Podocyte lateral migration in situ is unlikely.
  • Dynamic apical cell protrusions are observed under pathological conditions.
  • Different forms of motility (LTM, ATM, SM) are discussed in relation to podocytopathies.

Conclusions:

  • Podocytes exhibit limited motility in vivo, primarily through apical protrusions.
  • Understanding these dynamics is crucial for deciphering podocytopathies.
  • This review clarifies the current understanding of podocyte behavior in kidney health and disease.