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ROS-modulated therapeutic approaches in cancer treatment

Muhammad Hassan Raza1, Sami Siraj2, Abida Arshad3

  • 1Department of Bioinformatics and Biotechnology, International Islamic University, Sector H-10, Islamabad, 44000, Pakistan. Hassan.bsbt755@iiu.edu.pk.

Journal of Cancer Research and Clinical Oncology
|June 26, 2017
PubMed
Abstract

Insights

Cancer cells produce reactive oxygen species (ROS), which can be targeted for therapy. Manipulating ROS levels offers a promising strategy for selective cancer treatment, with human microbiota influencing treatment response.

Area of Science:

  • Biochemistry
  • Oncology
  • Microbiology

Background:

  • Reactive oxygen species (ROS) are integral to cancer cell metabolism and survival.
  • Dysregulated ROS levels are a hallmark of cancer, influencing proliferation and therapeutic sensitivity.

Purpose of the Study:

  • To review the multifaceted role of ROS in cancer development and progression.
  • To explore ROS-mediated therapeutic strategies for selective cancer targeting.
  • To examine the influence of the human microbiota on ROS-dependent cancer therapy.

Main Methods:

  • Comprehensive literature search of PubMed, Web of Science, and Google Scholar.
  • Analysis of peer-reviewed articles, clinical studies, and reviews on ROS in biological systems.
  • Focus on ROS production, cancer roles, therapeutic strategies, and microbiota interactions.

Main Results:

  • Tumor oxidative stress and ROS adaptations are key features of cancer cells.
  • ROS-scavenging and ROS-boosting therapies demonstrate efficacy in preclinical and clinical settings.
  • The human microbiota significantly modulates cancer therapy outcomes.

Conclusions:

  • Cancer cells' altered redox homeostasis creates vulnerabilities exploitable by ROS-targeted therapies.
  • ROS-dependent therapeutic approaches, including scavenging and boosting, show significant promise.
  • Microbiota plays a critical role in modulating cancer therapy response and systemic functions.
Keywords:
AntioxidantsCancer therapyMicrobiotaPro-oxidantsReactive oxygen species

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