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A speculated cause of respiratory inhibition in infants

Hideki Minowa1, Ikuyo Arai1, Hajime Yasuhara1

  • 1a Department of Neonatal Intensive Care Unit , Nara Prefecture General Medical Center , Nara , Japan.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 27, 2017
PubMed

Insights

Respiratory inhibition in infants is linked to perinatal factors. Umbilical cord compression is a suspected primary cause, impacting infant breathing shortly after birth.

Area of Science:

  • Neonatal Medicine
  • Perinatology
  • Pediatric Neurology

Background:

  • Previous studies identified threatened premature labor and intrauterine growth restriction as risk factors for respiratory inhibition.
  • Respiratory inhibition poses a significant risk to infant well-being.

Purpose of the Study:

  • To investigate the causes of respiratory inhibition by analyzing perinatal risk factors.
  • To identify specific perinatal factors associated with respiratory inhibition in term and near-term infants.

Main Methods:

  • A cohort of 1497 infants (gestational age ≥ 36 weeks) was studied.
  • Infants underwent pulse oximetry monitoring and cranial sonography.
  • Respiratory inhibition was defined by severe hypoxemia or respiratory pauses during feeding, crying, or reflux.

Main Results:

  • Respiratory inhibition occurred in 422 infants.
  • Significant correlations were found between respiratory inhibition and shorter gestational age, twin pregnancies, lateral ventricle enlargement, and increased echogenicity in the ganglionic eminence.
  • Cranial sonography revealed abnormalities in a substantial portion of the infants.

Conclusions:

  • Umbilical cord compression is hypothesized as a major cause of respiratory inhibition.
  • Perinatal factors, including specific sonographic findings, are strongly associated with respiratory inhibition.
Abstract

Keywords:
Twin pregnancyhypoxemiapulse oximetryrespiratory inhibitionsonography

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