Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.0K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.0K
Esophagus01:24

Esophagus

4.1K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
4.1K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.3K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.3K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.0K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.0K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

771
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
771
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

851
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
851

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma.

The British journal of surgery·2022
Same author

Optimising Multimodality Treatment of Resectable Oesophago-Gastric Adenocarcinoma.

Cancers·2022
Same author

Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study.

Nature cancer·2022
Same author

Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study.

Nature cancer·2022
Same author

Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer.

Lancet (London, England)·2022
Same author

Heat increases full-length SMN splicing: promise for splice-augmenting therapies for SMA.

Human genetics·2022

Related Experiment Video

Updated: Feb 27, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K

Oesophageal cancer.

Jesper Lagergren1, Elizabeth Smyth2, David Cunningham2

  • 1Division of Cancer Studies, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, UK; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Lancet (London, England)
|June 27, 2017
PubMed
Summary
This summary is machine-generated.

Oesophageal cancer management is complex, involving multidisciplinary care and evolving treatments like endoscopy and neoadjuvant therapy. Advances improve prognosis, but challenges in quality of life and palliative care persist.

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

874
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.2K

Related Experiment Videos

Last Updated: Feb 27, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

874
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.2K

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Oesophageal cancer presents significant clinical challenges, often necessitating a multidisciplinary approach.
  • While extensive treatments can impact quality of life, recent decades show improved prognoses for oesophageal cancer.
  • Early-stage and premalignant oesophageal tumours increasingly benefit from endoscopic interventions.

Purpose of the Study:

  • To offer insights into the current clinical management of oesophageal cancer.
  • To discuss ongoing controversies in oesophageal cancer treatment and research.
  • To highlight future needs and directions in oesophageal cancer care.

Main Methods:

  • Review of current clinical practices in oesophageal cancer management.
  • Analysis of neoadjuvant therapies (chemotherapy, chemoradiotherapy) in locally advanced disease.
  • Examination of surgical standardization and centralization trends.
  • Evaluation of therapeutic options for palliative care in oesophageal cancer.

Main Results:

  • Endoscopic procedures are gaining prominence for early oesophageal tumours.
  • Neoadjuvant therapy is now a standard adjunct to surgery for advanced oesophageal cancer.
  • Surgical approaches are becoming more standardized and centralized, improving outcomes.
  • Diverse palliative treatment strategies are available for advanced stages.

Conclusions:

  • The management of oesophageal cancer requires a comprehensive, multidisciplinary strategy.
  • Ongoing research and clinical trials are crucial for addressing treatment controversies and improving patient outcomes.
  • Future efforts should focus on enhancing quality of life alongside survival rates in oesophageal cancer patients.