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Targeting the Thioredoxin System for Cancer Therapy

Junmin Zhang1, Xinming Li2, Xiao Han2

  • 1State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.

Trends in Pharmacological Sciences
|June 27, 2017
PubMed
Summary

The thioredoxin (Trx) system, including thioredoxin reductase (TrxR), regulates cellular redox signaling and tumor development. Targeting TrxR/Trx with small-molecule inhibitors shows promise for cancer treatment, despite challenges.

Keywords:
cancer therapyreactive oxygen speciesredox regulationselenocysteinethioredoxin

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