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Stability enhanced, repeatability improved Parylene-C passivated on QCM sensor for aPTT measurement.
Yuchen Yang1, Wei Zhang2, Zhen Guo2
1CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Biosensors & Bioelectronics
|June 27, 2017
Summary
A novel Parylene-C passivated quartz crystal microbalance (P-QCM) sensor enhances activated partial thromboplastin time (aPTT) measurement. This P-QCM offers improved stability, reproducibility, and signal-to-noise ratio for point-of-care testing.
Area of Science:
- Biomedical Engineering
- Materials Science
- Analytical Chemistry
Background:
- Accurate blood clotting time measurement is crucial for managing anticoagulant therapies.
- Existing methods may lack the sensitivity or stability required for rapid diagnostics.
Purpose of the Study:
- To develop and evaluate a Parylene-C passivated quartz crystal microbalance (P-QCM) for activated partial thromboplastin time (aPTT) measurement.
- To assess the performance improvements of P-QCM compared to traditional quartz crystal microbalances (QCM).
Main Methods:
- Fabrication of P-QCM sensors with a hydrophobic Parylene-C surface.
- Characterization of P-QCM surface properties and frequency response.
- Measurement of aPTT using P-QCM and comparison with a standard hematology analyzer (SYSMEX CS 2000i).
Main Results:
- P-QCM demonstrated enhanced hydrophobicity, leading to effective fibrin adsorption.
- Increased peak-to-peak value (1.94% ± 0.63%) indicated improved signal-to-noise ratio compared to typical QCM.
- High stability and reproducibility were observed with coefficients of variation of 2.58% for frequency decrease and 1.24% for aPTT.
- Excellent linearity was confirmed with a clinical coefficient of determination (R²) of 0.983 against the SYSMEX CS 2000i.
Conclusions:
- P-QCM technology significantly improves the stability, reproducibility, and linearity of piezoelectric sensors for aPTT measurement.
- The developed P-QCM sensor shows strong potential for point-of-care testing (POCT) applications in coagulation diagnostics.
