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Related Experiment Video

Updated: Feb 27, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
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Two new protostane-type triterpenoids from Alisma orientalis.

Xiu-Lan Xin1,2, Xin-Yu Zhao2,3, Xiao-Kui Huo2

  • 1a College of Bioengineering , Beijing Polytechnic , Beijing , China.

Natural Product Research
|June 27, 2017
PubMed
Summary
This summary is machine-generated.

Two new compounds, 17-epi alisolide and 24-epi alismanol D, were isolated from Alisma orientalis. Compound 2 showed moderate inhibitory activity against HCE-2 cells.

Keywords:
Alisma orientalisHCE-2protostane-type triterpenoid

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Area of Science:

  • Natural Products Chemistry
  • Pharmacology

Background:

  • Alisma orientalis is a traditional medicinal plant.
  • Triterpenoids are a class of natural compounds with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new compounds from Alisma orientalis.
  • To evaluate the inhibitory effects of isolated compounds on HCE-2 cells.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structural elucidation using NMR, UV, and HRESIMS.
  • In vitro bioactivity assay against HCE-2 cells.

Main Results:

  • Two new protostane-type triterpenoids, 17-epi alisolide (1) and 24-epi alismanol D (2), were identified.
  • Compound 2 exhibited moderate inhibitory activity against HCE-2 cells with an IC50 value of 23.1 μM.

Conclusions:

  • Alisma orientalis is a source of novel triterpenoids.
  • 24-epi alismanol D shows potential as an HCE-2 inhibitor.