Related Experiment Video
Updated: Jan 9, 2026
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
Dual-channel signals for intracellular mRNA detection via a PRET nanosensor
Tao Xie1, Meng Li, Yi-Tao Long
1Key Laboratory for Advanced Materials & School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. ytlong@ecust.edu.cn.
Abstract:
An intracellular nanosensor was designed and developed to accurately sense mRNA in living cells without false positive results. This nanosensor consists of gold nanoparticles assembled with recognition sequences and dye-labelled nanoflares. By analyzing both the wavelength shifts and intensity recovery of the scattering spectra, this dual-channel nanosensor could efficiently distinguish and avoid the interference induced by other common substances. This novel dual-channel nanosensor would precisely recognize the target mRNA, and it is promising for further cancer diagnoses.
More Related Videos
08:14Detection of Intracellular Gene Expression in Live Cells of Murine, Human and Porcine Origin Using Fluorescence-labeled Nanoparticles
Published on: November 13, 2015
12:20Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
Published on: August 6, 2014